tPA Deficient Products

Tissue Plasminogen Activator (tPA) Genetically Deficient (Knockout) Products are applicable to a wide range of in vitro research applications (including ELISA and Western Blot) and for many different areas of research, including cardiovascular and neurological studies. 

Our tPA Knockout was created by targeted disruption of the PLAT gene. Mutations were then confirmed using PCR genotyping and Sanger sequencing. These knockouts demonstrate a complete absence of tPA expression as confirmed by Western Blot of brain tissue lysates, and loss of tPA activity as confirmed by ELISA.

Products available include genetically deficient plasma, organs (flash-frozen), lyophilized organ powders, and ready-to-use organ tissue lysates. These products are ideal for use as standards or controls, including use as a negative control. 

We also offer Knockout Mice, available as individual male and/or female mice as well as breeding pairs. These Research Models are fully licensed and maintained as live colonies with immediate availability. Contact us directly for more information about live Research Models.