Rabbit Anti Human CASR Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,Sandwich ELISA) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.05% sodium azide and 40% Glycerol, pH7.4 This antibody has been purified using Antigen Affinity Purified.More Details: Host: Rabbit Species: Human Target: CASR Clonality: Polyclonal Purity: Antigen Affinity Purified Immunogen: Fusion protein of human CASR Storage Conditions: Store at -20░C. Avoid freeze / thaw cycles. CASR (Calcium Sensing Receptor) is a Protein Coding gene. Diseases associated with CASR include Hypocalcemia, Autosomal Dominant and Hyperparathyroidism, Neonatal. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase binding. An important paralog of this gene is GPRC6A.The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.This product can be used in analytical tools such as IHC,Sandwich ELISA.At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.For research use only.
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