Product References — Human Plasma

Mouse Non-Swiss Albino Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy Shyam H. Kamble, Francisco León, Tamara I. King, Erin C. Berthold, Carolina Lopera-Londoño, Kanumuri Siva Rama Raju, Aidan J. Hampson, Abhisheak Sharma, Bonnie A. Avery, Lance R. McMahon, and Christopher R. McCurdy ACS Pharmacology & Translational Science July 31, 2020 Kratom is commonly used in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom, and...

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Evaluating the Quantity, Quality and Size Distribution of Cell-Free DNA by Multiplex Droplet Digital PCR Miguel Alcaide, Matthew Cheung, Jack Hillman, S. Rod Rassekh, Rebecca J. Deyell, Gerald Batist, Aly Karsan, Alexander W. Wyatt, Nathalie Johnson, David W. Scott & Ryan D. Morin Scientific Reports July 28, 2020 Since their initial description in 1948, small DNA fragments travelling outside the cells in internal bodily fluids and excretions have revolutionized numerous fields in public health and preventive medicine. Cell-free DNA (cfDNA) is generally thought to arise...

Single Donor Human Whole Blood, Single Donor Human Plasma (Blood Derived), Single Donor Human Complement Serum, Innovative Grade US Origin Porcine Plasma, and Innovative Grade US Origin Porcine Whole Blood from Innovative Research were used in the following study:   Development of a Sensitive Assay to Screen Nanoparticles in vitro for Complement Activation Nuzhat Maisha, Tobias Coombs, and Erin B. Lavik American Chemical Society July 6, 2020 Nanomedicines are often recognized by the innate immune system as a threat, leading to unwanted clearance due to complement activation. This unwanted reaction not only alters the bioavailability of the therapeutic, but can...

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   An miRNA Fingerprint Using Neural-Enriched Extracellular Vesicles from Blood Plasma: Towards a Biomarker for Amyotrophic Lateral Sclerosis/Motor Neuron Disease Sandra Anne Banack, Rachael Anne Dunlop and Paul Alan Cox The Royal Society Publishing May 22, 2020 Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) continue to provide challenges for diagnosis since validated diagnostic biomarkers are currently unavailable. Rapid diagnosis and intervention in the disease process could be beneficial in slowing neurodegenerative disease progression as well...

Pooled Human AB Serum Plasma Derived Heat Inactivated from Innovative Research was used in the following study:   Human Interleukin-4–Treated Regulatory Macrophages Promote Epithelial Wound Healing and Reduce Colitis in Mouse Model Timothy S. Jayme, Gabriella Leung, Arthur Wang, Matthew L. Workentine, Sruthi Rajeev, Adam Shute, Blanca E. Callejas, Nicole Mancini, Paul L. Beck, Remo Panaccione, Derek M. McKay Science Advances June 5, 2020 Murine alternatively activated macrophages can exert anti-inflammatory effects. We sought to determine if IL-4–treated human macrophages [i.e., hM(IL4)] would promote epithelial wound repair and can serve as a cell transfer treatment for inflammatory bowel disease (IBD)....