Product References — Human Plasma

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Development of a Linker Mediated Immunoassay Using Chemically Transitioned Nanosensors Lucas D Smith, Michael Charles Willard, Jordan P. Smith, and Brian T. Cunningham Analytical Chemistry 2/8/2020 “Sensitive and specific quantification of protein biomarkers is important in medical diagnostics, academic research, and pharmaceutical development. However, multiple binding steps in conventional sandwich immunoassay protocols result in high assay hands-on-time and delayed results. This is particularly relevant for medical diagnostics, where assay turn-around-time can have an immense impact on patient outcomes. …CTNI samples were prepared using PBS or...

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Measurement of Thrombolysis Enhanced by EkoSonic Catheter-Based Endovascular Therapy Alexander Hannah, Misty L. Noble-Vranish, Curtis Genstler IEEE International Ultrasonics Symposium 6-9 Oct. 2019 “…Ultrasound (US) imaging is a valuable tool to visualize and measure the underlying anatomy and physiology indicative of vascular pathology. Imaging can identify the location and severity of thrombosis, and it can monitor interventions. It has been widely used for guidance in HIFU-based therapies… Pooled normal human plasma was obtained from Innovative Research (Novi, MI)…”   Related products available from Innovative Research...

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity Lee Faulkner, Andrew Gibson, Andrew Sullivan, Arun Tailor, Toru Usui, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park Toxicological Sciences, Volume 154, Issue 2 December 2016 “…A number of serious adverse drug reactions are caused by T cells. An association with HLA alleles has been identified with certain reactions, which makes it difficult to develop standardized preclinical tests to predict chemical liability....

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry J.J.M Rood, M.J.van Haren, J.H.Beijnen, R.W.Sparidans Journal of Pharmaceutical and Biomedical Analysis January 2020 “…Osimertinib is a “third-generation’’ oral, irreversible, tyrosine kinase inhibitor. It is used in the treatment of non-small cellular lung carcinoma and spares wild-type EGFR. Due to its reactive nature, osimertinib is, in addition to oxidative routes, metabolized through GSH coupling and subsequent further metabolism of these conjugates. The extent of the non-oxidative metabolism...

Single Donor Human Serum Off The Clot, Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities Dmytro S. Kulyk, Devin J. Swiner, Taghi Sahraeian, and Abraham K. Badu-Tawiah Analytical Chemistry August 26, 2019 “Accurate and rapid analysis of complex microsamples are challenging tasks in translational research. Nanoelectrospray ionization (nESI) is the method of choice for analyzing small sample volumes by mass spectrometry (MS), but this technique works well only for polar analytes. Herein, we...