Mouse Noggin Recombinant Protein Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in with a purity of Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per and#956;g (1EU/and#956;g)..More Details: Species: Mouse Target: Nog Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per and#956;g (1EU/and#956;g). Source: E. coli Storage Conditions: The lyophilized Noggin recombinant protein is stable for at least 2 years from date of receipt at -20░C. Reconstituted Noggin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20░C. As with any protein, exposing Noggin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Additional Information:

Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-and#946; family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-and#946; ligands and their natural anTagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 anTagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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