Human IL-6 Receptor alpha Recombinant Protein Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in with a purity of ? 95% by SDS-PAGE gel and HPLC analyses..More Details: Species: Human Target: IL6R Purity: ? 95% by SDS-PAGE gel and HPLC analyses. Source: CHO cells Storage Conditions: The recombinant protein is stable for at least 2 years from date of receipt at -20░C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20░C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Additional Information:
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R? and gp130. While the IL-6R? chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6R?. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R? alone. IL-6R? is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6R?, which consists of only the extracellular domain of the IL-6R? chain, acts as an agonist of IL-6 activity at low concentrations. CHO cell-derived Recombinant Human sIL-6 Receptor ? is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6R?. As a result of glycosylation, Recombinant Human sIL-6 Receptor ? migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.
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