Human / Mouse Frizzled-5 Recombinant Protein Fc Tag Lyophilized

Human / Mouse Frizzled-5 Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in HEK293 cells. This is a Lyophilized protein buffered in Contains PBS. Reconstitute with 50 and#956;l sterile water. with a purity of >95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ and#956;g purified protein (LAL test; Lonza)..

More Details:

• Species: Human, Mouse
• Target: FZD5
• Purity: >95% (SDS-PAGE).
  
  Endotoxin level is less than 0.01EU/ and#956;g purified protein (LAL test; Lonza).
• Source: HEK293 cells
• Storage Conditions: Stable for at least 6 months after receipt when stored at -20°C.

Additional Information:

Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.

This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herein are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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