Product References — Human Serum

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T-Cells are Selectively Activated with Amoxicillin-Peptide Adducts Arun Tailor, Xiaoli Meng, Kareena Adair, John Farrell, James C Waddington, Ann Daly, Munir Pirmohamed, Gordon Dear, B Kevin Park, Dean J Naisbitt Toxicological Sciences August 10, 2020 Idiosyncratic drug-induced liver injury (DILI) is a major health concern often associated with a high patient death rate. Amoxicillin-clavulanate is the most common cause of DILI, and the detection of drug-specific CD4+ T-cells in patients with DILI suggests it originates somewhere in the immune system....

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Effect of Intravenous Immunoglobulin (IVIg) on Primate Complement-Dependent Cytotoxicity of Genetically Engineered Pig Cells: Relevance to Clinical Xenotransplantation Takayuki Yamamoto, Yehua Cui, Diyan Patel, Abhijit Jagdale, Hayato Iwase, David Ayares, David K. C. Cooper & Hidetaka Hara Scientific Reports July 16, 2020 Triple-knockout (TKO) pigs are thought to be ideal sources of organs for clinical xenotransplantation because many humans have no preformed antibody to TKO pig cells. Pig kidney or heart graft survival in nonhuman primates (NHPs) now extends to many months, or in...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...

Single Donor Human Whole Blood, Single Donor Human Plasma (Blood Derived), Single Donor Human Complement Serum, Innovative Grade US Origin Porcine Plasma, and Innovative Grade US Origin Porcine Whole Blood from Innovative Research were used in the following study:   Development of a Sensitive Assay to Screen Nanoparticles in vitro for Complement Activation Nuzhat Maisha, Tobias Coombs, and Erin B. Lavik American Chemical Society July 6, 2020 Nanomedicines are often recognized by the innate immune system as a threat, leading to unwanted clearance due to complement activation. This unwanted reaction not only alters the bioavailability of the therapeutic, but can...

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Old World Monkeys are Less than Ideal Transplantation Models for Testing Pig Organs Lacking Three Carbohydrate Antigens (Triple-Knockout) Takayuki Yamamoto, Hayato Iwase, Diyan Patel, Abhijit Jagdale, David Ayares, Douglas Anderson, Devin E. Eckhoff, David K. C. Cooper & Hidetaka Hara Scientific Reports June 17, 2020 Choosing the best nonhuman primate (NHP) model to perform pig-to-NHP xenotransplantation is crucial to determine the feasibility of pig organ transplantation in humans. Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs...