Product References — Human Blood Cells

Single Donor Human Whole Blood, Single Donor Human Plasma (Blood Derived), Single Donor Human Complement Serum, Innovative Grade US Origin Porcine Plasma, and Innovative Grade US Origin Porcine Whole Blood from Innovative Research were used in the following study:   Development of a Sensitive Assay to Screen Nanoparticles in vitro for Complement Activation Nuzhat Maisha, Tobias Coombs, and Erin B. Lavik American Chemical Society July 6, 2020 Nanomedicines are often recognized by the innate immune system as a threat, leading to unwanted clearance due to complement activation. This unwanted reaction not only alters the bioavailability of the therapeutic, but can...

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Evaluation of Peptoid Mimics of Short, Lipophilic Peptide Antimicrobials R. Madison Green, Kevin L. Bicker International Journal of Antimicrobial Agents June 6, 2020 For patients recovering from surgery or dealing with weakened immune systems, nosocomial infections are a serious complication and may be fatal. These infections can be acquired through improper hygiene or inadequately cleaned surfaces. The ESKAPE pathogens, which include Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp., are identified as the bacteria most often responsible for resistant,...

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Environmentally Benign Nanoantibiotics with a Built-in Deactivation Switch Responsive to Natural Habitats Wan ZhengWan Zheng, Miguel Anzaldua, Ankita Arora, Yunjiang Jiang, Kelly McIntyre, Michael Doerfert, Theodora Winter, Abhijit Mishra, Hairong Ma, and Hongjun Liang* American Chemical Society March 23, 2020 “In the battles against bacterial infections in healthcare and agriculture, antibiotics have been used at a massive scale for many decades. It was estimated that the annual antibiotics consumption reached 100 000−200 000 tons in 2010 worldwide, and up to 90% of the administered...

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species Dean A. Rowe-Magnus, Adenine Y. Kao, Antonio Cembellin Prieto, Meng Pu, Cheng Kao American Society for Microbiology 10 September 2019 ”… All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro, purportedly by assembling into higher-order structures that perforate the membrane. We utilized high-resolution, single-cell fluorescence microscopy to examine their mechanism of action in real time....

Single Donor Human Buffy Coats Leukocytes from Innovative Research was used in the following study:   Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes Jeannie M. Camarillo, Suchitra Swaminathan, Nebiyu A. Abshiru, Jacek W. Sikora, Paul M. Thomas, Neil L. Kelleher Journal of The American Society for Mass Spectrometry 08 July 2019 “…Histone posttranslational modifications (PTMs) are essential for regulating chromatin and maintaining gene expression throughout cell differentiation. Despite the deep level of understanding of immunophenotypic differentiation pathways in hematopoietic cells, few studies have investigated global levels of histone PTMs required for differentiation...