Proteolytic Cleavage of HLA Class II by Human Neutrophil Elastase in Pneumococcal Pneumonia

Proteolytic Cleavage of HLA Class II by Human Neutrophil Elastase in Pneumococcal Pneumonia

Posted by Adam Awdish on

Human Neutrophil Elastase Purified Lyophilized from Innovative Research was used in the following study:

 

Proteolytic Cleavage of HLA Class II by Human Neutrophil Elastase in Pneumococcal Pneumonia

Hisanori Domon, Tomoki Maekawa, Toshihito Isono, Kazuyuki Furuta, Chikara Kaito, and Yutaka Terao

Scientific Reports
January 28, 2021

Respiratory infections caused by bacteria and viruses can lead to acute lung injury and respiratory distress. One of the key mediators of acute respiratory failure are neutrophils and their granule enzymes. Although neutrophil elastase acts as a defensive factor against pathogens in the host, its leakage into airway spaces causes degradation of the connective tissues of the host, which causes disruptions in the host’s innate immune responses.

Researchers in this study investigated whether neutrophils have proteases that cleave immune molecules. Their observations indicated that expression of certain human leukocyte antigen (HLA) class II molecules was decreased in macrophages treated with supernatants from dead neutrophils. This indicates that neutrophil elastase leakage may disrupt immune responses, T-cell activation, and antigen presentation.

 

Related products available from Innovative Research also include:

Human Pai 1 Recombinant Mutant Neutrophil Elastase Inhibitor

Single Donor Human Red Blood Cells Washed

Single Donor Human Plasma (Blood Derived)

  • Tags: Human Biological Fluids

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