Posted by Adam Awdish on
Human Neutrophil Elastase Purified Lyophilized from Innovative Research was used in the following study:
Hisanori Domon, Tomoki Maekawa, Toshihito Isono, Kazuyuki Furuta, Chikara Kaito, and Yutaka Terao
January 28, 2021
Respiratory infections caused by bacteria and viruses can lead to acute lung injury and respiratory distress. One of the key mediators of acute respiratory failure are neutrophils and their granule enzymes. Although neutrophil elastase acts as a defensive factor against pathogens in the host, its leakage into airway spaces causes degradation of the connective tissues of the host, which causes disruptions in the host’s innate immune responses.
Researchers in this study investigated whether neutrophils have proteases that cleave immune molecules. Their observations indicated that expression of certain human leukocyte antigen (HLA) class II molecules was decreased in macrophages treated with supernatants from dead neutrophils. This indicates that neutrophil elastase leakage may disrupt immune responses, T-cell activation, and antigen presentation.
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