Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Posted by Corey Marcath on

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:

 

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Lee Faulkner, Andrew Gibson, Andrew Sullivan, Arun Tailor, Toru Usui, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park

Toxicological Sciences, Volume 154, Issue 2
December 2016

“…A number of serious adverse drug reactions are caused by T cells. An association with HLA alleles has been identified with certain reactions, which makes it difficult to develop standardized preclinical tests to predict chemical liability. We have recently developed a T cell priming assay using the drug metabolite nitroso sulfamethoxazole (SMX-NO). We now report on reproducibility of the assay, establishment of a biobank of PBMC from 1000 HLA-typed volunteers, and generation of antigen-specific responses to a panel of compounds... The AB serum was purchased from Innovative Research (Novi, Michigan)…”

 

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  • Tags: Human Plasma, Pooled Human AB Serum Plasma Derived

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