Mouse Anti Human KI67 Monoclonal Clone 8K5

Mouse Anti Human KI67 Monoclonal Clone 8K5 from Innovative Research is a monoclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide and 50% glycerol pH 7.4. This antibody has been purified using Protein A purification.

More Details:

• Host: Mouse
• Species: Human,Mouse,Rat
• Target: MKI67
• Clonality: Monoclonal
• Immunogen: Synthetic Peptide
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

This product can be used in analytical tools such as IHC-p,Immunofluorescence.

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For research use only.