Trimethylamine N-oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

Trimethylamine N-oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

Posted by Corey Marcath on

Pooled Human Complement Serum from Innovative Research was used in the following study:

 

Trimethylamine N-oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

Bowen Li, Priyesh Jain, Jinrong Ma, Josh K. Smith, Zhefan Yuan, Hsiang-Chieh Hung, Yuwei He, Xiaojie Lin, Kan Wu, Jim Pfaendtner, and Shaoyi Jiang

Science Advances
2019 Jun 14

”…Materials that resist nonspecific protein adsorption are needed for many applications. However, few are able to achieve ultralow fouling in complex biological milieu. Zwitterionic polymers emerge as a class of highly effective ultralow fouling materials due to their superhydrophilicity, outperforming other hydrophilic materials such as poly(ethylene glycol). Unfortunately, there are only three major classes of zwitterionic materials based on poly(phosphorylcholine), poly(sulfobetaine), and poly(carboxybetaine) currently available. …Then, 300 μl of pooled complement human serum (Innovative Research, Novi, MI) was added into replicates of each polymer bowl (n = 3) and incubated at 37°C for 90 min, and followed by quenching with 30 μl of 10 mM EDTA solution…”

 

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  • Tags: Human Serum, Pooled Human Complement Serum

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