Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib

Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib

Posted by Adam Awdish on

Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated HRP Labeled from Innovative Research was used in the following study:

 

Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib

Yusuke Yamashita, Shuhei Morita, Hiroki Hosoi, Hiroshi Kobata, Shohei Kishimoto, Tatsuya Ishibashi, Hiroyuki Mishima, Akira Kinoshita, Bradley J. Backes, Koh-Ichiro Yoshiura, Feroz R. Papa, Takashi Sonoki, and Shinobu Tamura

International Journal of Molecular Sciences
August 31, 2020

Inositol-requiring enzyme 1α (IRE1α) and protein kinase R-like endoplasmic reticulum kinase (PERK) are key regulators of the unfolded protein response (UPR). The UPR is a cellular mechanism that helps ensure unfolded proteins do not leave the endoplasmic reticulum of a cell. Recent discoveries have shown that kinase-inhibiting RNase attenuator 6 (KIRA6), an IRE1α inhibitor, showed potential for use as a treatment against multiple myeloma (MM). Researchers in this study analyzed the treatment potential of combining KIRA8 and nilotinib, an existing drug approved by the FDA, for use in fighting myeloma.

 

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Rabbit Anti Mouse IgG Polyclonal Affinity Purified

Anti Mouse C1 Inhibitor Clone 7D10

Monkey Cynomolgus IgG Affinity Purified

  • Tags: Antibodies

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