Posted by Adam Awdish on
Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated HRP Labeled from Innovative Research was used in the following study:
Yusuke Yamashita, Shuhei Morita, Hiroki Hosoi, Hiroshi Kobata, Shohei Kishimoto, Tatsuya Ishibashi, Hiroyuki Mishima, Akira Kinoshita, Bradley J. Backes, Koh-Ichiro Yoshiura, Feroz R. Papa, Takashi Sonoki, and Shinobu Tamura
International Journal of Molecular Sciences
August 31, 2020
Inositol-requiring enzyme 1α (IRE1α) and protein kinase R-like endoplasmic reticulum kinase (PERK) are key regulators of the unfolded protein response (UPR). The UPR is a cellular mechanism that helps ensure unfolded proteins do not leave the endoplasmic reticulum of a cell. Recent discoveries have shown that kinase-inhibiting RNase attenuator 6 (KIRA6), an IRE1α inhibitor, showed potential for use as a treatment against multiple myeloma (MM). Researchers in this study analyzed the treatment potential of combining KIRA8 and nilotinib, an existing drug approved by the FDA, for use in fighting myeloma.
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