Product References — Human Biological Fluids

Biomarkers in Cancer Patients at Risk for Venous Thromboembolism: Data from the AVERT Study

Posted by Adam Awdish on

Biomarkers in Cancer Patients at Risk for Venous Thromboembolism: Data from the AVERT Study

Human tPA 85% Single Chain Purified from Innovative Research was used in the following study:   Biomarkers in Cancer Patients at Risk for Venous Thromboembolism: Data from the AVERT Study Anton Ilich, Vaibhav Kumara, Michael Henderson, Ranjeeta Mallick, Philip Wells, Marc Carrier, Nigel S. Key Elsevier Ltd. July 28, 2020 Currently, cancer-associated venous thromboembolism (VTE) and the ways it can develop are not well characterized. Scientists know that the risk of VTE varies depending on the type of cancer, however, the various mechanisms surrounding VTE are not thoroughly understood. In a study published this Summer, researchers selected several biomarkers that...

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Platelet-Primed Interactions of Coagulation and Anticoagulation Pathways in Flow-Dependent Thrombus Formation

Posted by Adam Awdish on

Platelet-Primed Interactions of Coagulation and Anticoagulation Pathways in Flow-Dependent Thrombus Formation

Human Protein C Activated Purified GLA Domainless from Innovative Research was used in the following study:   Platelet-Primed Interactions of Coagulation and Anticoagulation Pathways in Flow-Dependent Thrombus Formation Sanne L. N. Brouns, Johanna P. van Gefen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni & Johan W. M. Heemskerk Scientific Reports (Nature Publisher Group) 2020 During the processes of haemostasis and thrombosis, platelet and coagulation pathways are tightly linked,...

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CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Posted by Adam Awdish on

CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD Yuki Imura, Makoto Ando, Taisuke Kondo, Minako Ito, and Akihiko Yoshimura JCI Insight July 23, 2020 Tregs suppress excess immunity responses against a variety of antigens, including self-antigens, bacteria–derived antigens, and environmental allergens. Thus, Tregs have been shown to play important roles in suppressing the development of allergies. In humans, some clinical trials of transfer of ex vivo expanded polyclonal Tregs have been performed to suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem...

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Evaluation of Viscoelastic Properties, Blood Coagulation, and Cellular Responses of a Temperature-Sensitive Gel for Hemostatic Application

Posted by Corey Marcath on

Evaluation of Viscoelastic Properties, Blood Coagulation, and Cellular Responses of a Temperature-Sensitive Gel for Hemostatic Application

Single Donor Human Whole Blood from Innovative Research was used in the following study:   Evaluation of Viscoelastic Properties, Blood Coagulation, and Cellular Responses of a Temperature-Sensitive Gel for Hemostatic Application Joseph Jun, Reid C. Millican, Jennifer A. Sherwood, Bernabe S. Tucker, Vineeth M. Vijayan, Grant C. Alexander, Vinoy Thomas, Brigitta C. Brott, and Patrick T. J. Hwang ACS Applied Bio Materials 4/7/2020 “Hemorrhagic blood loss from traumatic injury is the leading cause of death in severe accidents and combat injuries. Treating and stopping blood loss in a timely and effective manner is essential for the survival of the patient…...

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Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography–triple quadrupole mass spectrometry method for determination of intact growth factor proteins

Posted by Corey Marcath on

Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography–triple quadrupole mass spectrometry method for determination of intact growth factor proteins

Pooled Human Urine and Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography–triple quadrupole mass spectrometry method for determination of intact growth factor proteins Alex J. Rai Kevin A. Schug, Katarína Maráková Journal of Separation Science 2/7/2020 “In biological systems, variable protein expression is a crucial marker for numerous diseases, including cancer. The vast majority of liquid chromatography–triple quadrupole mass spectrometry-based quantitative protein assays use bottom-up methodologies, where proteins are subjected to proteolytic cleavage prior to analysis. …As biological...

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