Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients is Associated with Underlying Non-Inflamed Tumor Profile

Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients is Associated with Underlying Non-Inflamed Tumor Profile

Posted by Adam Awdish on

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:

 

Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients is Associated with Underlying Non-Inflamed Tumor Profile

Rania H. Younis, Ioana Ghita, Manar Elnaggar, Risa Chaisuparat, Vasileios Ionas Theofilou, Donita Dyalram, Robert A. Ord, Eduardo Davila, Luke J. Tallon, John C. Papadimitriou, Tonya J. Webb, Søren M. Bentzen, and Joshua E. Lubek

Frontiers in Immunology
March 11, 2021

Semaphorin 4D (Sema4D) is a glycoprotein that is capable of functioning as both a membrane bound protein or as a cleaved soluble protein (sSema4D), and it is expressed by several different tumors and types of immune cells. Researchers in this study aimed to investigate the potential of plasma sSema4D as an immune marker in patients with head and neck squamous cell carcinoma (HNSCC). They observed significant changes in gene expression and inflammatory responses, however these associations could not be readily explained. The researchers did conclude, however, that there is a link between sSema4D and a patient’s histological inflammatory subtype.

 

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  • Tags: Human Plasma, Single Donor Human Plasma Whole Blood Derived

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