Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor α-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells

Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor α-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells

Posted by Adam Awdish on

Pooled Human Charcoal Dextran Stripped Serum from Innovative Research was used in the following study:

 

Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor α-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells

Dahae Lee, Young-Mi Kim, Young-Won Chin, and Ki Sung Kang

Pharmaceutics
July 15, 2021

Estrogen is a naturally occurring steroid hormone responsible for the development of the female reproductive system; the effects of estrogen are exhibited once estrogen binds to the estrogen receptor (ER) in a cell. Within the cell nucleus, the ERs bind to DNA and promotes the development of both normal breast cells and tumorous breast cells. Estrogen also likely plays a significant role in the later development of post-menopausal diseases as many are thought to result from a deficiency of endogenous estrogen.

Traditional treatment for postmenopausal symptoms typically involves estrogen replacement therapy, however long-term use of these treatment programs can lead to serious side effects like hypertension, breast cancer, and even dementia. Because of this, the exploration of alternatives, such as plant-derived estrogen (phytoestrogens), has been a growing area of medical research. This study used Charcoal Dextran Stripped Human Serum from Innovative Research to examine the estrogen-like effects of a selection a phytoestrogens, and the results indicated potential for therapeutic use and can serve as the basis for future research into the application of phytoestrogens for the prevention of postmenopausal symptoms.

 

Related products available from Innovative Research also include:

Pooled Human Plasma (Blood Derived)

Single Donor Human Red Blood Cells Washed

Pooled Human Serum Off The Clot

  • Tags: Human Serum, Pooled Human Charcoal Dextran Stripped Serum, Pooled Human Charcoal Stripped Serum

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