Posted by Leanne Kodsman on
Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological SystemALTEX preprint, published 08 July 2018
Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb and Kenneth E. Thummel
"The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in the rodent models, this time using a 3-dimensional proximal tubule microphysiological system incorporating primary human proximal tubule epithelial cells ... Human receptor-associated protein (RAP) was purchased from Innovative Research (Novi, MI) ... The effect of RAP on each intrinsic clearance was evaluated using ratio t-tests paired by kidney tissue donor (n=5 biological replicates, all from male donors)."
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