Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System

Posted by Leanne Kodsman on

Human Receptor Associated Protein (RAP) from Innovative Research was recently used in the following study:

Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System

ALTEX preprint, published 08 July 2018
Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb and Kenneth E. Thummel

"The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in the rodent models, this time using a 3-dimensional proximal tubule microphysiological system incorporating primary human proximal tubule epithelial cells ... Human receptor-associated protein (RAP) was purchased from Innovative Research (Novi, MI) ... The effect of RAP on each intrinsic clearance was evaluated using ratio t-tests paired by kidney tissue donor (n=5 biological replicates, all from male donors)."

Related products available from Innovative Research also include:

  • Tags: Proteins

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!



    ← Older Post Newer Post →