Posted by Adam Awdish on
Salwa M. Harbi, Rania A. Hussien, Intesar Hawasawi, Ibtehaj Alshdoukhi, Vikram Chopra, Amal N. Alanazi, William Butler, Rakia Koroma, Colin Peters, Deanne D. Garver, and Joe A. Vinson
Journal of Agricultural and Food Chemistry
June 4, 2020
Dietary polyphenols are protective agents in the body against chronic diseases. Polyphenols bind to proteins and cells in blood including RBC, albumin and lipoproteins described in this study. This potentially benefits both proteins and RBC as polyphenols bind to amino acids as well as lipids in lipoproteins. Dietary polyphenols have been well documented in epidemiology studies since 1993 to reduce the risk of chronic diseases such as cardiovascular disease. Polyphenols are extensively metabolized in both the GI tract (microbial catabolites) and in the systemic circulation, and recently there has been emphasis on the investigation of these metabolites. Their blood transport has not been well investigated, so this study examines multiple classes of polyphenols and their interactions with albumin, lipoproteins and red blood cell (RBC) compartments using four models of increasing complexity and determines the percent of polyphenol in each compartment. Polyphenols can also, we hypothesize, bind to and enter other cells in the bloodstream. With the albumin wash described in this work, researchers could accurately determine how much of a polyphenol (or a drug) can bind to a cell and how much can enter the cell. Since polyphenols are antioxidants they can protect cells and proteins in the blood from oxidation by their association with the cells. This study used Innovative Grade US Origin Porcine Plasma from Innovative Research, Inc.
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