Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection

Posted by Corey Marcath on

Innovative Grade US Origin Rat Sprague Dawley Whole Blood from Innovative Research was used in the following study:

 

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection

Barbara A. Bensing, Liang Li, Olga Yakovenko, Maurice Wong, Karen N. Barnard, T. M. Iverson, Carlito B. Lebrilla, Colin R. Parrish, Wendy E. Thomas, Yan Xiong, Paul M. Sullam

PLOS Pathogens
2019 Jun 24

“…Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal species express a serine-rich repeat surface adhesin that mediates attachment to sialylated glycans on mucin-like glycoproteins, but the specific sialoglycan structures recognized can vary from strain to strain. …Rat platelets were prepared from sodium citrate-treated pooled Sprague-Dawley rat blood (Innovative Research, Novi MI)…”

 

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  • Tags: Animal Whole Blood, Innovative Grade US Origin Rat Sprague Dawley Whole Blood

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