Platelet Factor 4 as a Novel Exosome Marker in MALDI-MS Analysis of Exosomes from Human Serum

Platelet Factor 4 as a Novel Exosome Marker in MALDI-MS Analysis of Exosomes from Human Serum

Posted by Corey Marcath on

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:

 

Platelet Factor 4 as a Novel Exosome Marker in MALDI-MS Analysis of Exosomes from Human Serum

Huu-Quang Nguyen, Dabin Lee, Yeoseon Kim, Minseok Paek, Minsun Kim, Kyoung-Soon Jang, Jooyeon Oh, Young-Sun Lee, Jong Eun Yeon, David M. Lubman, and Jeongkwon Kim

Analytical Chemistry
September 24, 2019

“…Exosomes are nanosized vesicles commonly found in biological fluids as a result of a secretion process involving endosomes and multivesicular bodies. The isolation and analysis of exosomes can be useful for noninvasive clinical diagnosis of a variety of human diseases. We investigated the utility of analyzing exosomal proteins, using matrix-assisted laser desorption/ionization combined with Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS), as a means of determining the presence of exosomes. MALDI-FTICR-MS analyses of exosomes enriched from human serum via centrifugation in a mass range of m/z 1000−20 000 yielded a distinctive protein around m/z 7766. …Pooled normal human serum samples were obtained from Innovative Research (Novi, MI)... “

 

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  • Tags: Human Serum, Pooled Human Serum Off The Clot

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