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Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Posted by Leanne Kodsman on

Pooled Normal Human Plasma from Innovative Research was recently used in the following study:

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Mansi Shah, Meixiang Xu, Poonam Shah, Xiaoming Wang, Shannon M. Clark, Maged Costantine, Holly A. West, Tatiana N. Nanovskaya, Mahmoud S. Ahmed, Sherif Z. Abdel-Rahman, Raman Venkataramanan, Steve N. Caritis, Gary D. V. Hankins, Erik Rytting
European Journal of Drug Metabolism and Pharmacokinetics, August 2018

"... Plasma concentrations of indomethacin and DMI at steady state were analyzed with a validated LC-MS/MS method. DNA was isolated from subject blood and buccal smear samples. Subjects were grouped by genotype for comparisons of pharmacokinetic parameters ... Pooled blank human plasma was purchased from Innovative Research (Novi, MI) ..."

Related products available from Innovative Research also include:

  • Tags: Human Plasma, Pooled Human Plasma Apheresis Derived

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