Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis

Posted by Leanne Kodsman on

Mouse PAI-1 ELISA Kit from Innovative Research was recently used in the following study:

Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis

Sachiko Shioya, Takeshi Masuda, Tadashi Senoo, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Experimental and Therapeutic Medicine, August 2018

... PAI-1 and TGF-beta levels in BAL fluids were measured at 0, 4, 12, 18, and 24 weeks after irradiation using ELISA kits for PAI-1 (Innovative Research, Novi, MI, USA)... To determine the effect of thoracic irradiation on the expression of PAI-1 and TGF-beta in the lung, PAI-1 and TGF-beta levels in BAL fluid were measured using ELISA kits. In WT mice, PAI-1 levels in BAL fluids were unchanged from baseline until 12 weeks after irradiation but started increasing after 18 weeks and reached their highest levels at 24 weeks after irradiation..."

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