Mathematical modeling of the “inoculum effect”: six applicable models and the MIC advancement point concept
Posted by Corey Marcath on
Innovative Grade US Origin Horse Whole Blood Lysed from Innovative Research was used in the following study:
Jessica R. Salas, Majid Jaberi-Douraki, Xuesong Wen, Victoriya V. Volkova
FEMS Microbiology Letters
21 January 2020
“…Antimicrobial treatment regimens against bacterial pathogens are designed using the drug’s minimum inhibitory concentration (MIC) measured at the bacterial density of 5.7 log10(colonyforming units (CFU)/mL) in vitro. However, MIC changes with pathogen density, which varies among infectious diseases and during treatment. Incorporating this into treatment design requires realistic mathematical models of the relationships. We compared the MIC-density relationships for Gramnegative Escherichia coli and nontyphoidal Salmonella enterica subsp. enterica and Gram-positive Downloaded from https://academic.oup.com/femsle/advance-article-abstract/doi/10.1093/femsle/fnaa012/5710933 by guest on 24 February 2020 Staphylococcus aureus and Streptococcus pneumonia (for n=4 drug-susceptible strains per (sub)species and 1-8 log10(CFU/mL) densities), for antimicrobial classes with bactericidal activity against the (sub)species: β-lactams (ceftriaxone and oxacillin), fluoroquinolones (ciprofloxacin), aminoglycosides (gentamicin), glycopeptides (vancomycin), and oxazolidinones (linezolid). …For an isolate of S. pneumoniae, bacterial colonies from the BAP were suspended to the expected bacterial density ~1x108 – 5x108 CFU/mL in 9 mL of Ca-MHB with 5% (v/v) lysed horse blood (Innovative Research, Inc., Novi, MI, U.S.)...”
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