In vitro study of new combinations for local antibiotic therapy with calcium sulphate – Near constant release of ceftriaxone offers new treatment options
Posted by Leanne Kodsmann on
Innovative Grade US Origin Bovine Plasma from Innovative Research was used in the following study:
Peter Wahl, Karolin Rönn, Marc Bohner, Laurent A Decosterd, Christoph Meier, Michel Schläppi, Sandrine Festa, Emanuel Gautier
Journal of Bone and Joint Infection, October 2018
"... For every antibiotic, 5 g of pellets were placed in each of four closed glass tubes. The elution experiment was run in triplicate, while the fourth tube allowed sampling of whole pellets for agar diffusion tests. Each tube was filled with 10 ml of elution fluid, exchanged daily by pouring it out and refilling. As the aim of the experiment was to assess stability and activity of the antibiotics over a prolonged period of time, no thorough rinsing of the pellets was performed in order to avoid accidental losses of material and drug washout. The experiment was run once with isotonic phosphate-buffered saline ... and then repeated with bovine plasma (IBV-K2 EDTA, lot 11035, Innovative Research, Novi, MI, USA) for those antibiotics that showed prolonged stability in the first phase ..."
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