Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation

Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation

Posted by Corey Marcath on

Single Donor Human Complement Serum from Innovative Research was used in the following study:

 

Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation

Qi Li, Takayuki Yamamoto, Hayato Iwase, Huy Quoc Nguyen, Yi Wang, David Ayares, David K.C.Cooper, Hidetaka Hara

Transplant Immunology
December 2019

“…Background: Measurement of serum anti-pig antibodies is an important parameter in immune monitoring after pig-to-nonhuman primate xenotransplantation. Pig aortic endothelial cells (pAECs) are commonly used for this purpose. However, human (h) CTLA4-Ig (abatacept/belatacept) could bind to pCD80/86 on the cells, and a secondary antibody (i.e., anti-human IgG) may recognize hCTLA4-Ig (in the absence of serum anti-pig IgG antibody binding to pAECs), potentially leading to misinterpretation of the results. Our aim was to determine whether hCTLA4-Ig binding to pAECs is associated with false-positive results… Commercially-available human complement was purchased from Innovative Research (Novi, MI)…”

 

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  • Tags: Human Serum, Single Donor Human Complement Serum

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