Posted by Adam Awdish on
Mouse Total Fibrinogen ELISA Kit from Innovative Research was used in the following study:
Jeong Yeon Kim, Dipankar Manna, Trygve B. Leergaard, Sandip M. Kanse
January 12, 2022
Factor VII activating protease (FSAP) is a serine protease associated with cell adhesion, and patients diagnosed with the Marburg I (MI) single nucleotide polymorphism (SNP) have an increased chance of stroke due to inactivation of the FSAP enzyme. Observations in both human patients that have suffered a stroke and in vitro mouse models have shown raised plasma FSAP levels and data from in vitro mouse models suggests that FSAP promotes fibrinolysis among other cytotoxicity-decreasing mechanisms. Since this is the desired result following treatment for a stroke, this study looked to investigate the effect the recombinant serine protease domain of FSAP (FSAP-SPD) has on ischemic strokes in mouse models.
Researchers observed faster clotting in a thromboembolic stroke model, indicating pro-coagulant effects resulting from the treatment. Further, when co-treated with tissue plasminogen activator (tPA) there appeared to be a decreased risk of negative outcomes in stroke treatment, making this a promising new method of treatment for ischemic stroke.
Related products available from Innovative Research also include: