Estrogenic Activity of Mycoestrogen (3β,5α,22E)-Ergost-22-en-3-ol via Estrogen Receptor α-Dependent Signaling Pathways in MCF-7 Cells

Estrogenic Activity of Mycoestrogen (3β,5α,22E)-Ergost-22-en-3-ol via Estrogen Receptor α-Dependent Signaling Pathways in MCF-7 Cells

Posted by Adam Awdish on

Pooled Human Charcoal Dextran Stripped Serum from Innovative Research was used in the following study:

 

Estrogenic Activity of Mycoestrogen (3β,5α,22E)-Ergost-22-en-3-ol via Estrogen Receptor α-Dependent Signaling Pathways in MCF-7 Cells

Dahae Lee, Yuri Ko, Changhyun Pang, Yoon-Joo Ko, You-Kyoung Choi, Ki Hyun Kim, and Ki Sung Kang

Molecules
December 22, 2021

Estrogen replacement therapy has commonly been used as a treatment for the relief and prevention of postmenopausal symptoms and other similar diseases. Unfortunately, long-term patients receiving estrogen therapy are often reluctant to continue their treatment due to the risk of serious side effects including breast cancer, heart disease, and stroke. Considering the risks associated with traditional estrogen replacement therapy, there is growing interest in the use of safer alternatives to mammalian estrogens.

One group of interest are phytoestrogens, natural compounds found in plants and plant-based foods that are often structurally, and even functionally, like mammalian estrogens and their metabolites. Despite their structural and functional similarities to traditional mammalian estrogens, studies suggest that phytoestrogens do not present the same potential health risks as traditional estrogens, and some data has indicated that phytoestrogens may even have cancer-inhibiting effects.

Mycoestrogens, a naturally occurring group of fungal-derived compounds with estrogen-like mechanisms, can be produced in various Fusarium species and are very similar in structure to phytoestrogens. They have been reported to act as agonists to estrogen receptors. The chemical mechanisms that create the estrogen-like effects of mushrooms are still not well understood, however, so this group of researchers sought to discover the bioactive compounds found in Korean wild mushrooms. After a series of tests, they were able to isolate four steroids and four fatty acids they believe to be responsible for the estrogen-like activity of a. tabescens, a mushroom of the Tricholomataceae family.

 

Related products available from Innovative Research also include:

Pooled Human Serum Off The Clot

Pooled Human Plasma (Blood Derived)

Single Donor Human Whole Blood

  • Tags: Human Biological Fluids, Human Serum, Pooled Human Charcoal Dextran Stripped Serum, Pooled Human Charcoal Stripped Serum

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