Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells

Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells

Posted by Adam Awdish on

Innovative Grade US Origin Monkey Rhesus Whole Blood from Innovative Research was used in the following study:

 

Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells

Madhumithra Subramanian Karthikesh, Sa Wu, Rohit Singh, Yannis Paulus, Xueding Wang and Xinmai Yang

Applied Sciences
March 3, 2022

Photo-mediated ultrasound therapy (PUT) is a form of non-invasive imaging technique that uses synchronized ultrasound bursts and laser pulses to produce a photoacoustic image and seems to be very precise in blood vessel targeting. Further, PUT has been shown to cause limited damage to healthy tissues surrounding the area of treatment. PUT works by enhancing cavitation activity within the targeted vessels, inducing strong mechanical stresses. These stresses impact the function of platelets, red blood cells, and endothelial cells in blood vessels. Said changes may cause coagulation, hemorrhaging, and vasoconstriction.

The effects of ultrasound treatments on vascular endothelial cells are of particular interest due to the powerful physiological effects endothelial cells have on the body. Thus, the impact of ultrasound on endothelial cells has been studied for possible applications in the fields of drug delivery, gene therapy, injury recovery, DNA and protein synthesis, cancer treatment, and more.

Nitric oxide (NO) helps to regulate many functions in the body, and it can be released when changes in blood flow cause endothelial stress. Along with NO, prostacyclin (PGI2) is released from endothelial cells and, together, they form a specific association that helps in the regulation of vascular and platelet function.

In this study, researchers developed a novel vascular model based on the polydimethylsiloxane (PDMS) channel. PDMS is safe, stable, biocompatible, and hemocompatible, and is widely used in developing in vitro blood vessel models. The newly-developed model has a biologically inert surface to prevent microbial growth and make it ideal for biomedical applications, and is also very permeable to gases, making it ideal for in vitro cell cultivation. Further, the channel is coated with type I collagen, fibrin, or fibronectin to promote cellular adhesion. Previous in vitro studies of endothelial cells involved treating them in Petri dishes or well plates, which are not ideal representations of in vivo models. This new model is aimed at creating a more accurate representation of the changes in PGI2 and NO released from vascular endothelial cells during PUT.

 

Related products available from Innovative Research also include:

Innovative Grade US Origin Monkey Cynomolgus Whole Blood

Innovative Grade US Origin Bovine Whole Blood

Rat Sprague Dawley Plasma

  • Tags: Animal Blood Cells, Animal Whole Blood, Innovative Grade US Origin Monkey Rhesus Whole Blood

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!


    Related Posts

    Detection of SARS-CoV-2 RNA through Tandem Isothermal Gene Amplification without Reverse Transcription
    Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following ...
    Read the Article
    Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis
    Pooled Human Serum Off The Clot from Innovative Research was used in the following stud...
    Read the Article
    PD-LAMP Smartphone Detection of SARS-CoV-2 on Chip
    Pooled Human Saliva from Innovative Research was used in the following study:   PD-LAM...
    Read the Article

    ← Older Post Newer Post →

    ×