Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities

Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities

Posted by Corey Marcath on

Single Donor Human Serum Off The Clot, Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:

 

Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities

Dmytro S. Kulyk, Devin J. Swiner, Taghi Sahraeian, and Abraham K. Badu-Tawiah

Analytical Chemistry
August 26, 2019

“Accurate and rapid analysis of complex microsamples are challenging tasks in translational research. Nanoelectrospray ionization (nESI) is the method of choice for analyzing small sample volumes by mass spectrometry (MS), but this technique works well only for polar analytes. Herein, we describe a versatile dual noncontact nESI/nAPCI (nanoatmospheric pressure chemical ionization) source that allows simultaneous detection of both polar and nonpolar analytes in microliter quantities of samples under ambient conditions and without pretreatment. The same device can be activated to enable electrophoretic separation… Both single-donor human blood and single-donor human serum were obtained from Innovative Research (Novi, MI, USA)...”

 

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  • Tags: Human Plasma, Human Serum, Single Donor Human Plasma Whole Blood Derived, Single Donor Human Serum Off The Clot

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