Differentiation of 2‐hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry

Differentiation of 2‐hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry

Posted by Corey Marcath on

Single Donor Human Serum Off The Clot from Innovative Research was used in the following study:

 

Differentiation of 2‐hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry

Shinji K. Strain, Morris D. Groves, Mark R. Emmett

Rapid Communications in Mass Spectrometry
11 May 2019

“…2‐Hydroxyglutaric acid (2‐hg) is a dicarboxylic acid with a hydroxyl group at the alpha carbon, forming the enantiomers (R)‐2‐ hydroxyglutaric acid (R‐2‐hg) (Figure 1A) and (S)‐2‐hydroxyglutaric acid (S‐2‐hg) (Figure 1B).1 Though detectable in normal tissues, the detection of 2‐hg enantiomers in bodily fluids first gained traction in patients with 2‐hydroxyglutaric acidurias, a disease which leads to pathologically increased levels of either enantiomer.2,3. …Serum samples acquired from ten individual healthy donors were obtained from Innovative Research (Novi, MI, USA)…”

 

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  • Tags: Human Serum, Single Donor Human Serum Off The Clot

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