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Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acidsJournal of Controlled Release Volume 286, 28 September 2018, Pages 46-54
Sam Chen, Josh Zaifman, Jayesh A. Kulkarni, Igor V. Zhigaltsev, Ying K. Tam, Marco A. Ciufolini, Yuen Yi C. Tam, Pieter R. Cullis
"... The ability of LNP to cause hemolysis was assessed as follows. Briefly, human erythrocytes (RBC) (Innovative Research, Novi, MI) were washed three times with cold isotonic saline (0.9% w/v NaCl in water) and resuspended in pH 7.4 PBS to a final concentration of 4% vol/vol. LNP (with or without LD003) were then incubated with the RBC solution for 1 h at 37 degrees C..."
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