Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids

Posted by Leanne Kodsman on

Single Donor Human Red Blood Cells from Innovative Research were recently used in the following study:

Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids

Journal of Controlled Release Volume 286, 28 September 2018, Pages 46-54
Sam Chen, Josh Zaifman, Jayesh A. Kulkarni, Igor V. Zhigaltsev, Ying K. Tam, Marco A. Ciufolini, Yuen Yi C. Tam, Pieter R. Cullis

"... The ability of LNP to cause hemolysis was assessed as follows. Briefly, human erythrocytes (RBC) (Innovative Research, Novi, MI) were washed three times with cold isotonic saline (0.9% w/v NaCl in water) and resuspended in pH 7.4 PBS to a final concentration of 4% vol/vol. LNP (with or without LD003) were then incubated with the RBC solution for 1 h at 37 degrees C..."

Related products available from Innovative Research also include:

  • Tags: Human Whole Blood, Single Donor Human Red Blood Cells Washed

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