Development of a Fast and Efficient Liposomal Drug Loading Technology for Poorly Water Soluble Drugs: Formulation, Characterization, and Potential Applications

Development of a Fast and Efficient Liposomal Drug Loading Technology for Poorly Water Soluble Drugs: Formulation, Characterization, and Potential Applications

Human Red Blood Cells and Sheep Red Blood Cells from Innovative Research were used in the following study:

 

Development of a Fast and Efficient Liposomal Drug Loading Technology for Poorly Water Soluble Drugs: Formulation, Characterization, and Potential Applications

Wei-Lun Tang

The University of British Columbia (Vancouver), October 2018

"... Human and sheep red blood cells (RBCs) for hemolysis test were purchased from Innovative Research (Novi, MI) ... complete hemolysis of human and sheep RBCs was observed 1 h post incubation with free GA (40 µg GA /mL + 44 µg arginine/mL), whereas Lipo-GA (40 or 200 µg GA/mL) only resulted in mild hemolysis (<7%), which was comparable with negative controls including the arginine solution (44 µg arginine/mL) and empty liposomes (1 mg total lipid/mL) ..."

 

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