Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino

Biomedical Chromatography
20 August 2019

“…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…”

Related products available from Innovative Research also include:

• Innovative Grade US Origin Rat Sprague Dawley Plasma
• Innovative Grade US Origin Mouse CD1 Plasma
• Innovative Grade US Origin Mouse C57BL6 Plasma