Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Posted by Corey Marcath on

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:

 

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino

Biomedical Chromatography
20 August 2019

“…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…”

 

Related products available from Innovative Research also include:

  • Tags: Animal Plasma, Innovative Grade US Origin Rat Sprague Dawley Plasma

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