Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

Single Donor Human Plasma from Innovative Research was used in the following study:

Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

Xun Bao, Jianmei Wu, Nader Sanai, Jing Li

Journal of Pharmaceutical and Biomedical Analysis
Volume 166, 20 March 2019, Pages 197-204

"... Drug-free (blank) human plasma from six different healthy donors and pooled plasma (with Na-EDTA anticoagulant) were purchased from Innovative Research Inc. (Novi, MI, USA) ... Frozen plasma and tumor samples were thawed at room temperature. Patient plasma samples were diluted 5-fold with blank human plasma to ensure measured drug concentration to fall within the calibration curve range (0.5–1000 nM )..."

Related products available from Innovative Research also include:

• Single Donor Human Plasma Whole Blood Derived
• Single Donor Human Pediatric Plasma
• Single Donor Human Pregnancy Plasma
• Human Cancer-State Products