Posted by Leanne Kodsman on
Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig PlasmaMartin Kertys, Anna Urbanova, and Juraj Mokry
Journal of Chromatographic Science: 10 July 2018
" ... K3 EDTA guinea pig plasma (blank plasma) was purchased from Innovative Research (Novi, MI, USA) ... in this study we decided to develop a rapid, specific and sensitive method using LC"MS-MS coupled with an easy and fast sample preparation by protein precipitation for the TD, RF and RFN determination in guinea pig plasma. The method was fully validated in terms of selectivity, stability, linearity, precision and accuracy for guinea pig plasma... "
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