Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Posted by Leanne Kodsmann on

Human Complement from Innovative Research was used in the following study:

 

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Tianjiao Duan, Alex J. Smith and Alan S. Verkman

Journal of Neuroinflammation, October 2018

"... Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank’s buffer, and cells were incubated at 37 °C for specified times. In some experiments, cells were exposed to serum of an AQP4-IgG seropositive NMO patient who met the revised diagnostic criteria for clinical disease. A fixable dead-cell stain (amine-reactive dye, Invitrogen, Eugene, OR) at 1:1000 dilution was added 30 min prior to cell fixation. In some experiments, C1q- or C6-deficient human complement (Innovative Research, Novi, MI) was used instead of normal complement ..."

 

Related products available from Innovative Research also include:

  • Tags: Human Deficient Plasma, human plasma, Human Serum, Journal: Journal of Neuroinflammation, pooled human complement plasma, Pooled Human Complement Serum, single donor human complement serum

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!


    Related Posts

    Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound
    Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were use...
    Read the Article
    A proteome-wide screen of Campylobacter jejuni using protein microarrays identifies novel and conformational antigens
    Pooled Human Serum from Innovative Research was used in the following study:   A prote...
    Read the Article

    ← Older Post Newer Post →