CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

Posted by Leanne Kodsmann on

Human Complement from Innovative Research was used in the following study:

 

CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

Lukmanee Tradtrantip, Tianjiao Duan, Michael R. Yeaman, Alan S. Verkman

Journal of Neuroinflammation
December 2019, 16:57

"... Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflammation. The increased NMO pathology in rodents deficient in complement regulator protein CD59 following passive transfer of AQP4-IgG has suggested the potential therapeutic utility of increasing the expression of complement regulator proteins...Human complement was purchased from Innovative Research (Novi, MI)..."

 

Related products available from Innovative Research also include:

  • Tags: Human Serum, Pooled Human Complement Serum, Single Donor Human Complement Serum

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