Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9 Partially through Protease-Activated Receptor-2 in Human Corneal Epithelial Cells

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9 Partially through Protease-Activated Receptor-2 in Human Corneal Epithelial Cells

Posted by Leanne Kodsmann on

Human Interleukin-8 (IL-8) ELISA Kit from Innovative Research was used in the following study:

 

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease—Activated Receptor-2, in Human Corneal Epithelial Cells

Wannita Klinngam, Runzhong Fu, Srikanth R. Janga, Maria C. Edman and Sarah F. Hamm-Alvarez

International Journal of Molecular Sciences
November 2018

"... Human corneal epithelial cells (HCE-T cells) were treated with recombinant human CTSS at activity comparable to that in SS patient tears for 2, 4, 8, and 24 h. Acute CTSS significantly increased HCE-T cell gene and protein expression of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) from 2 to 4 h, while matrix metalloproteinase 9 (MMP-9), CTSS, and protease-activated receptor-2 (PAR-2) were increased by chronic CTSS (24 h) ... The human IL-8 ELISA kit was from Innovative Research (Novi, MI, USA) ..."

 

Related products available from Innovative Research also include:

  • Tags: ELISA Kits, Human Interleukin-8 (IL-8) ELISA Kit

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!


    Related Posts

    An Edwardsiella piscicida esaS mutant reveals contribution to virulence and vaccine potential
    Sheep Red Blood Cells Packed 100% from Innovative Research was used in the following st...
    Read the Article
    Determination of tafenoquine in human plasma by dispersive liquid‐liquid microextraction
    Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the foll...
    Read the Article
    Antimicrobial properties of amylose-fatty ammonium salt inclusion complexes
    Sheep Red Blood Cells Packed 100% from Innovative Research was used in the following st...
    Read the Article

    ← Older Post Newer Post →