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Pooled Human Charcoal Dextran Stripped Serum from Innovative Research was used in the following study:
Seulah Lee, Dahae Lee, Rhim Ryoo, Jin-Chul Kim, Hyun Bong Park, Ki Sung Kang, and Ki Hyun Kim
Journal of Natural Products
September 17, 2020
The Calvatia species of mushrooms, also called puffball mushrooms, have widespread use as food source and medicinal ingredient, particularly in wound dressings. Calvatia nipponica is an extremely rare type of puffball mushroom with a limited number of studies on its chemical and biological functions. During a program to catalog new bioactive metabolites from wild Korean mushrooms the fruiting bodies of C. nipponica were investigated, and the identification of a novel sterol known as calvatianone, along with four other known steroids, was reported.
The structure of calvatianone was determined by NMR spectroscopic analyses, HR-ESIMS, gaugeincluding atomic orbital NMR chemical shift calculations, and ECD calculations. Data showed that ergosterol peroxide and cyathisterol suppressed the cell viability increase induced by 17β-estradiol in MCF-7 breast cancer cell lines, suggesting a possible approach for these compounds to serve as ERα antagonists in therapeutic uses.
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