B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

Posted by Corey Marcath on

Hamster Armenian IgG Affinity Purified from Innovative Research was used in the following study:

 

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

Hidde Douna, Jacob Amersfoort, Frank H. Schaftenaar, Mara J. Kro¨ ner, Ma´te´ G. Kiss, Bram Slu¨ tter, Marie A. C. Depuydt, Mireia N. A. Bernabe´ Kleijn, Anouk Wezel, Harm J. Smeets, Hideo Yagita, Christoph J. Binder, I. Bot, Gijs H. M. van Puijvelde, Johan Kuiper, and Amanda C. Foks

European Society of Cardiology
10 May 2019

“…Inflammation is a key process in the development of atherosclerosis. Components of both the innate and adaptive immune system contribute significantly to the pathology of atherosclerosis. The connection between these two arms of the immune system is provided by professional antigen-presenting cells (APCs). …For the initiation experiment, female Ldlr-/- mice (n = 11–12/group) were fed a WTD for 6 weeks, while either receiving an i.p. injection of PBS, an appropriate Armenian hamster isotype antibody (Innovative Research, Novi, MI; 100 mg/injection), or a nondepleting agonistic BTLA antibody15 (3C10; 100 mg/injection) twice a week…”

 

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