APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

Posted by Corey Marcath on

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:

 

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

Jung-Hwa Ryu, Mengyuan Ge, Sandra Merscher, Avi Z. Rosenberg, Marco Desante, Hila Roshanravan, Koji Okamoto, Myung K. Shin, Maarten Hoek, Alessia Fornoni, Jeffrey B. Kopp

PLOS ONE
April 18, 2019

”Genetic variants in APOL1, encoding apolipoprotein L1, constitute a major cause of glomerular disease in individuals with sub-Saharan African ancestry. These diseases include focal segmental glomerulosclerosis, collapsing glomerulopathies in various settings including HIV-associated nephropathy, and arterionephrosclerosis. …Pooled normal human serum used for cholesterol efflux assays in HeLa cells was purchased from Innovative Research, Novi, MI…”

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