Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate

Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate

Posted by Adam Awdish on

Innovative Grade US Origin Rat Sprague Dawley Serum from Innovative Research was used in the following study:

 

Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate

Robert J. Brosnan, Kimberly Ramos, Antonio Jose de Araujo Aguiar, Alessia Cenani, Heather K. Knych

Pharmacology
January 31, 2022

Many anesthetics in use today work via interactions with a select group of ion channel targets. Specifically, most anesthetics target γ-amino butyric acid type A (GABAA) and N-methyl-D-aspartate (NMDA) receptors, as well as type-2 voltage-gated sodium (Nav1.2) channels. While injectable anesthetics typically have a high affinity for one specific ion channel, inhaled anesthetics, on the other hand, usually can target a wider range of ion channels at the cost of a lower affinity towards them.

It is assumed that all hydrocarbons can modulate anesthetic-sensitive ion channels if the hydrocarbon’s molar water solubility exceeds the ion channel’s measured solubility cutoff. L-carvone and methyl salicylate, extracts from mint plants, have water solubility which exceeds the cutoff values for GABAA, NMDA, and Nav1.2 channels. Researchers in this study hypothesized that these extracts would modulate those channels in anesthetic concentrations in rat models. Their results not only indicated that the extracts were able to modulate the ion channels at anesthetic levels, but showed they also could induce general anesthesia.

 

Related products available from Innovative Research also include:

Rat Wistar Serum

Innovative Grade US Origin Mouse CD1 Plasma

Innovative Grade US Origin Bovine Whole Blood

  • Tags: Animal Serum, Innovative Grade US Origin Rat Sprague Dawley Serum, Rat Sprague Dawley Serum, Rat Wistar Serum

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!



    ← Older Post Newer Post →

    ×