An Autoantibody Profile Detects Brugada Syndrome and Identifies Abnormally Expressed Myocardial Proteins

An Autoantibody Profile Detects Brugada Syndrome and Identifies Abnormally Expressed Myocardial Proteins

Posted by Adam Awdish on

Single Donor Human Serum Off The Clot from Innovative Research was used in the following study:

 

An Autoantibody Profile Detects Brugada Syndrome and Identifies Abnormally Expressed Myocardial Proteins

Diptendu Chatterjee, Maurizio Pieroni, Meena Fatah, Flavien Charpentier, Kristopher S Cunningham, Danna A Spears, Dipashree Chatterjee, Gonca Suna, J Martjin Bos, Michael J Ackerman, Eric Schulze-Bahr, Sven Dittmann, Pasquale G Notarstefano, Leonardo Bolognese, Firat Duru, Ardan M Saguner, Robert M Hamilton

European Heart Journal
August 7, 2020

Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern is often transient, and a genetic cause is only identified in <25% of patients. This study sought to identify an additional biomarker for this rare condition. As myocardial inflammation may be present in BrS, researchers evaluated whether myocardial autoantibodies can be detected in these patients. A biomarker profile of autoantibodies against four cardiac proteins can be identified from sera of BrS patients and is highly sensitive and specific, irrespective of genetic cause for BrS. The four involved proteins are expressed abnormally in the myocardium of patients with BrS. This study used Single Donor Human Serum Off The Clot from Innovative Research as the control variable.

 

Related products available from Innovative Research also include:

Pooled Human Serum Off The Clot

Single Donor Human Plasma (Blood Derived)

Single Donor Human Complement Serum

  • Tags: academic research, Human Serum, Single Donor Human Serum Off The Clot

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