A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Posted by Corey Marcath on

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:

 

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon

Journal of Chromatography B
25 May 2019

“…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million adults worldwide in 2015; this number is expected to increase to 642 million by 2040 …Pooled plasma from male Sprague-Dawley rats was purchased from Innovative Research, Inc. (Novi, MI, USA)…”

 

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  • Tags: Animal Plasma, Innovative Grade US Origin Rat Sprague Dawley Plasma

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