What is tPA and Why is it Essential to Biomedical Science?
Tissue Plasminogen Activator (tPA) is an extraordinary enzyme with a life-saving role in biomedical science. By converting plasminogen into plasmin, tPA helps break down blood clots, a process central to maintaining healthy blood flow and preventing conditions such as thrombosis or stroke (National Center for Biotechnology Information, 2024). For researchers, tPA is more than just a clot-buster. It is a vital tool for investigating cardiovascular and cerebrovascular diseases, including stroke and heart attack, and for exploring new horizons such as drug delivery, immune regulation, cell signaling, and innovative gene therapies.
Researchers use tPA extensively in studies on fibrinolysis and clot dissolution, paving the way for better therapies and a deeper understanding of blood flow dynamics. Cutting-edge research has also placed tPA at the heart of advanced drug delivery techniques, including studies involving microbubbles and nanoparticles. Beyond its staple role in blood studies, tPA is advancing fields like immunology and neuroprotection, helping scientists unravel the mysteries of the immune system and the blood-brain barrier. Thanks to specialized ELISA kits for both humans and animal models, measuring tPA in research samples is now easier and more precise than ever (Innovative Research, 2024a; Innovative Research, 2024b).
The Impact of the Current tPA Shortage
These new frontiers in research are facing a challenge: a significant global shortage of tPA. Disruptions in supply chains and a surge in demand have forced many labs to delay projects or adapt study goals. For researchers with time-sensitive experiments, getting reliable tPA has become a source of uncertainty and frustration.
At Innovative Research, we understand the urgency. That’s why we are proud to offer tPA in stock and ready to ship. In 2024 our CEO realized the significance of having tPA for research purposes during this shortage, and made every effort possible to secure stock and create the products researchers rely on. It took many months but we are now one of the only suppliers of research use only tPA products that has stock on our shelves. Our product lineup includes high-purity human tPA created using recombinant technology in CHO cells, perfect for clotting and signaling studies. We also supply human tPA complexed with PAI-1—an ideal choice for protein-interaction and inhibition assays. For those working with animal models, our mouse tPA ELISA kits allow for rapid and accurate quantification. We also offer a human active tPA ELISA kit, giving you the ability to measure functionally active tPA in your samples with ease (Innovative Research, 2024a; Innovative Research, 2024b).
Every product goes through careful quality assurance and is available with bulk purchasing options. With overnight shipping, your research will never be kept waiting for crucial reagents.
See tPA in Action: Watch Our Expert Video
Want to discover more about tPA's importance in biomedical research, and why reliable supply matters? Watch our short video, "Exploring Human and Animal-sourced tPA from Innovative Research," for an inside look at tPA’s critical functions, research applications like thrombolytic therapy and cancer metastasis, and what sets Innovative Research apart as your partner in science.
Watch now on YouTube
What Makes Innovative Research the Right Choice for tPA?
· Reliable supply during industry shortages
· High purity, recombinant tPA with rigorous quality control
· Multiple product formats: from pure proteins to ready-to-use ELISA kits
· Expert support and guidance from experienced scientists
Keep Your Research Moving: Order tPA Today
Whether you are modeling clot breakdown, measuring tPA activity in samples, or exploring new therapies and biological pathways, Innovative Research has the products, support, and dependability your lab deserves. Avoid project delays and keep your science moving forward with high-quality tPA available for immediate shipment.
Ready to learn more? Contact our team today or place your order directly for the tPA products your research depends on.
References
Innovative Research. (2024a). Human tPA 95% two chain purified [Product information]. Innovative Research. https://www.innov-research.com/products/human-tpa-two-chain-purified
Innovative Research. (2024b). Mouse total tPA ELISA kit [Product information]. Innovative Research. https://www.innov-research.com/products/mouse-total-tpa-elisa-kit
National Center for Biotechnology Information. (2024). Harnessing micrometer-scale tPA beads for high plasmin generation and accelerated fibrinolysis. National Institutes of Health. https://pmc.ncbi.nlm.nih.gov/articles/PMC11580863/
