Kancera credits new drug with slowing pancreatic cancer tumor growth

Posted by Leanne Kodsman on

From the FierceBiotech Article:

Swedish drug developer Kancera says it has slowed the growth of pancreatic cancer tumors in preclinical animal trials with its first-generation PFKFB3 inhibitors.

The drug initially failed to work in an animal study involving human colon cancer, according to the company.


From the FierceBiotech Article:

Swedish drug developer Kancera says it has slowed the growth of pancreatic cancer tumors in preclinical animal trials with its first-generation PFKFB3 inhibitors.

The drug initially failed to work in an animal study involving human colon cancer, according to the company.

By blocking PFKFB3, the idea is to reduce the metabolism of the cancer tumors and starve its energy/food supply. PFKFB3 is believed to support cancer growth because it enables production of glucose, which cancer craves. Kancera claims that the drug generated a 20 reduction in pancreatic cancer tumor growth versus placebo treatment. That may not sound like a lot, but as the company notes, patients diagnosed with pancreatic cancer have a less than 2 survival rate 5 years after the diagnosis. And so Kancera insists that the initial promise PFKFB inhibitors show in reducing pancreatic cancer growth is license to proceed.

"That PFKFB inhibitors alone can reduce the growth of pancreatic cancer is very encouraging," CEO Thomas Olin said in a statement.

Kancera's initial results are encouraging but they're a long way from human trials. Coming next will be a bid to improve the drug properties of the company's PFKFB inhibitors and test how well they work to combat tumor growth combined with standard pancreatic cancer therapy.

Kancera isn't the only company targeting PFKFB3, whose full name is 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3.Advanced Cancer Therapeuticsis developing a possible brain cancer treatment with the same enzyme target in mind.

Innovative Research had nothing to do with this.....but we could have. Innovative Research offers high quality cancer serum, and plasma as well as brand new proteins and antibodies to specifically target the immune system. By providing cytokines and interleukins, Innovative Research hopes that the research community and laboratories all around the world will continue to provide results driven research.


    Innovative Research was established in 1998 after the realization that dependable, high-quality, and affordable research materials were hard to come by. Starting with core products like human plasma and serum, Innovative Research has grown to be a trusted supplier of all lab reagents, including human biologicals and ELISA kits. Today, we manufacture and supply thousands of high-quality human and animal biologicals including plasma, serum, tissues, and proteins.


Related Posts

PAI-1 Mutation in Amish Community Could Lead to New Treatments for Age-Related Disorders
In the early 1990s, a paper was published in the New England Journal of Medicine that d...
Read the Article
The case for PAI-1 as a biomarker for major depressive disorder and antidepressant resistance
If research dollars were allocated according to the extent of human distress, major dep...
Read the Article
Antigen, Abbreviated: Plasminogen Activator Inhibitor 1 (PAI-1)
What is PAI-1 and what does it do? Plasminogen Activator Inhibitor 1, commonly referred...
Read the Article

← Older Post Newer Post →

×