Brain Cells Have Greater Plasticity Than Previously Thought

Brain Cells Have Greater Plasticity Than Previously Thought

Posted by Leanne Kodsman on

While brain cells do not divide, and the ones a person is born with must last a lifetime, new research shows that overtime genes are turned on and off depending on the stimuli present.

Through a process called histone turnover gene expression can be altered in response to changes in the environment. In histone turnover, histone spools in brain cells, the place where genes are wound, are almost constantly being swapped out and replaced.


While brain cells do not divide, and the ones a person is born with must last a lifetime, new research shows that overtime genes are turned on and off depending on the stimuli present.

Through a process called histone turnover gene expression can be altered in response to changes in the environment. In histone turnover, histone spools in brain cells, the place where genes are wound, are almost constantly being swapped out and replaced.

The frequency with which the brain swaps out histone spools could explain its ability to adapt to changing circumstances.

Researchers at the Icahn School of Medicine at Mount Sinai and at Rockefeller University, according to GEN News, published an article noting that histone turnover regulates how genes in the brain are turned on and off in response to various stimuli, thereby allowing neurons to form new synaptic connections.

Scientists looked at H3.3, a version of histone H3, known to cause frequent histone turnovers when present in cells. Using a technique called 14C/12C bomb pulse, they measured turnover and confirmed through comparisons of samples from time of death and time of birth that H3.3 turnover does occur throughout life in the human brain.


    Innovative Research was established in 1998 after the realization that dependable, high-quality, and affordable research materials were hard to come by. Starting with core products like human plasma and serum, Innovative Research has grown to be a trusted supplier of all lab reagents, including human biologicals and ELISA kits. Today, we manufacture and supply thousands of high-quality human and animal biologicals including plasma, serum, tissues, and proteins.


Related Posts

Antigen, Abbreviated: Factor IX
What is Factor IX and what does it do? Factor IX, also referred to as Christmas Factor ...
Read the Article
Case closed? Genetic testing provides insight into unexplained sudden deaths of Amish children
An Amish family suffered a sudden and tragic event when one of their children died sudd...
Read the Article
PAI-1 Mutation in Amish Community Could Lead to New Treatments for Age-Related Disorders
In the early 1990s, a paper was published in the New England Journal of Medicine that d...
Read the Article

← Older Post Newer Post →