Amgen enzyme combats obesity, diabetes in monkeys

Posted by Leanne Kodsman on

Amgen (AMGN) has an interesting new weapon in the battle againstobesity. The company's scientists successfully used an antibody they discovered to make obese monkeys thinner, and also lower their levels ofinsulin,glucoseand triglycerides.


Amgen (AMGN) has an interesting new weapon in the battle againstobesity. The company's scientists successfully used an antibody they discovered to make obese monkeys thinner, and also lower their levels ofinsulin,glucoseand triglycerides.

Bloomberg offers a great summary of the study, which is detailed in the journal Science Translational Medicine. In short, the overweight monkeys lost 10 of their body weight. But according to the story, plans aren't set yet when, or whether, Amgen will start testing the antibody, mimAb1, in humans. As the article notes, however, the results point a possibly new way to treat humans withdiabetesand obesity.

More animal studies are needed before they reach that point, however, and there are no guarantees that the results can be repeated in human trials. That said, the Amgen researchers have a new drug with promise if subsequent testing can repeat the initial results, and ultimately prove the compound is safe to use. Their antibody is meant to mimic FGF21, a metabolic hormone in humans that regulates both glucose and lipid metabolism. Previous studies have shown that mice bread to produce FGF21 in abundance remained thinner and lived longer (though their bone density declined), the article explains.

But researchers haven't succeeded in making a drug out of FGF21, because its effects only last an hour or so, according to the story. But mimAb1 could be a much more viable drug because it lasted over a period of weeks after just two injections during the 11-week trial.

Obesity drugs don't get approved very often. According to the Bloomberg story, Vivus' (VVUS)Qsymiaand Arena Pharmaceuticals' (ARNA)Belviq, bothapproved this year, were the first to gain theFDA's nod to treat obesity since 1999.

Innovative has been supplying Amgen with research reagents for over 3 years. Innovative Research has developed several antibodies and proteins for research on diabetes and obesity. Our prolactin proteins and prolactin antibodies as well as our high quality animal serum and human serum have been used to further the research in obesity and diabetes.


    Innovative Research was established in 1998 after the realization that dependable, high-quality, and affordable research materials were hard to come by. Starting with core products like human plasma and serum, Innovative Research has grown to be a trusted supplier of all lab reagents, including human biologicals and ELISA kits. Today, we manufacture and supply thousands of high-quality human and animal biologicals including plasma, serum, tissues, and proteins.


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