Select this product for Molecular Innovations name, Human PAI-1 (Vitronectin binding reduced stable mutant) and product number, CPAI-Q123K.Human PAI-1 Recombinant Stable Mutant Vitronectin Binding Reduced from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 and a purity of >95% as determined by SDS-PAGE. More Details: Species: Human Target: PAI-1 Purification Method: Affinity purified Purity: >95% as determined by SDS-PAGE Analysis Source: E. coli Storage Conditions: -70 C

Additional Information:

Human PAI-1 has four mutations (K154T, Q319L, M354I and N150H) that combine to create stability in the labile molecule, "locking" it to its active conformation. This product modifes the stable mutant through Q123K point mutation to produce PAI-1 with a greatly extended half life that demonstrates a ten-fold reduction in vitronectin binding. This product can be used as a control in applications like ELISA and Western Blot. It can be used for a wide range of in vitro applications, including affinity purification, blocking, fibrinolysis, hypertension studies, inhibition, plasminogen activation, protein-protein interactions, receptor binding, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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